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Prakki Sai Rama Sridatta
Senior Bioinformatician
I deal with Bacterial Genomes, characterize them and analyze transmission patterns in Carbapenem-Resistant Enterobacteriaceae (CRE) working closely with The Carbapenemase-producing Enterobacteriaceae in Singapore (CaPES) study group in Singapore. My work includes backing up and maintenance of the sequence data, develop and validate pipelines for bacterial genomics data, Genome annotation and Pan Genome, SNP calling and validation.
Research Interests
I am a bioinformatician with a specialization in bacterial genomics. My current research focuses on using genomic data to understand the genetic and molecular basis of bacterial traits, such as antibiotic resistance and virulence. Bacteria are incredibly diverse organisms that play critical roles in many aspects of our lives, from maintaining a healthy microbiome in our bodies to driving nutrient cycles in the environment.
By studying their genomes, we can gain insights into the evolutionary history and biology of bacteria, as well as develop new strategies for controlling their growth and spread. In my work, I use a range of computational tools and techniques, including comparative genomics, phylogenetics, and functional annotation, to analyze large-scale genomic datasets from diverse bacterial species. I am passionate about using genomics to advance our understanding of bacterial biology and contribute to the development of new therapies and interventions for bacterial diseases.
Publications
Dominant Carbapenemase-Encoding Plasmids in Clinical Enterobacterales Isolates and Hypervirulent Klebsiella pneumoniae, Singapore. Emerging Infectious Diseases, 28(8), p.1578.
​Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales. Nature communications. 2022 Jun 1;13(1):3052.
CPgeneProfiler: A lightweight R package to profile the Carbapenamase genes from genome assemblies. Journal of Open Source Software, 5(54), p.2473.